Yinherb Custom Peptide MOTS-C/MOTS Bulk powder
Name: MOTS-c
CAS No. : 1627580-64-6
Sequence:H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Molecular formula: C101H152N28O22S2
Molecular weight : 2174.6
Purity: 95 %
Source: synthetic
MSDS and COA: available
Appearance: White Powder
Minimum Order Quantity: 1 g
Brand Name: Yinherb
Test Method: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below-18° C.
Peptide sequence of MOTS-C:
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insul.in Resistance:
What is MOTS-C/MOTS Peptide?
MOTS-c was composed of Met, Arg, Trp, Gln, Glu, Met, Gly, Tyr, Ile, Phe, Tyr, Pro, Arg, Lys, Leu, and Arg residues, which were synthesized by China Peptides Co., Ltd. with over >98% purity. The peptides were dissolved in ddH2O, and aliquots were frozen at -20°C until use.
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome.
MOTS-c targets muscle and regulates metabolism via the folate-purine-AM.PK pathway.
MOTS-c mediates mitochondrial regulation of insu.lin and metabolic homeostasis.
MOTS-c protects against age- and diet-dependent insu.lin resistance and obesity.
MOTS-C/MOTS Peptide Benefits
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA.
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insu.lin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AM.PK activation.
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insu.lin resistance, as well as diet-induced obesity. These results suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.
MOTS-C/MOTS Peptide HPLC &NMR Test report by Yinherb
Q1: Can i get some samples
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).
Q3: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery leadtime
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is there a discount
A:Different quantity has different discount.
Q7: How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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