Yinherb Lab High Purity 99% Raw Material Avibactam/NXL-104 Powder CAS 1192491-61-4
Product name: avibactam sodium
CAS No:1192491-61-4
Appearance: white powder
Molecular weight: 287.226
Molecular formula:C7H10N3NaO6S
Usage: Avibactam sodium is a covalent and reversible β-lactamase inhibitor, inhibits β-lactamase TEM-1 and CTX-M-15 with IC50 of 8 nM and 5 nM, respectively.
Assay: HPLC; HNRM; LC-MS
[Solubility]:Soluble in ethanol. Partly soluble in water.
[Specs] NLT 99%, Food Grade, Pharmaceutical Grade
Capacity: 1000kgs per month
Source: synthetic
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat.
What is Avibactam/NXL-104?
Avibactam is a non-β-lactam β-lactamase inhibitor developed by Actavis (now Allergan) jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime (branded as Avycaz) was approved by the FDA on February 25, 2015, for treating complicated urinary tract (cUTI) and complicated intra-abdominal infections (cIAI) caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant Gram-negative bacterial pathogens.
Avibactam/NXL-104 Benefits
The -lactamase serine nucleophilic attack avibatanamide bond, open loop to form a covalent bond, the enzyme - inhibitor complex, as an enzyme inhibition form, without hydrolysis, and then cyclization to form a lactam ring to get Avibatan Chemicalbook tan. The nucleophilic attack leads to the rate of ring-opening much higher than that of cyclization, resulting in the inhibition of-lactamase. In this process, the structure of Avibatan itself can be restored by the reverse reaction, so it has a long-term inhibitory effect.
It is one of the most promising new -lactamase inhibitors. Compared with the three listed -lactamase inhibitors, they are long-acting and covalently binding to enzyme reversibility, and do not induce -lactamase production.
Avibactam/NXL-104 HPLC &NMR Test report by Yinherb
Q1: Can i get some samples
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow
Q3: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery leadtime
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is there a discount
A:Different quantity has different discount.
Q7: How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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